Inherited hematological disorders due to defects in coat protein (COP)II complex
نویسندگان
چکیده
منابع مشابه
"موارد طحال برداری در بیماریهای خونی"splenectomy in hematological disorders" "
چکیده ندارد.
15 صفحه اولThe Serotonin Transporter Is an Exclusive Client of the Coat Protein Complex II (COPII) Component SEC24C*
The transporters for serotonin (SERT), dopamine, and noradrenaline have a conserved hydrophobic core but divergent N and C termini. The C terminus harbors the binding site for the coat protein complex II (COPII) cargo-binding protein SEC24. Here we explored which SEC24 isoform was required for export of SERT from the endoplasmic reticulum (ER). Three lines of evidence argue that SERT can only e...
متن کاملCOPII–Golgi protein interactions regulate COPII coat assembly and Golgi size
Under experimental conditions, the Golgi apparatus can undergo de novo biogenesis from the endoplasmic reticulum (ER), involving a rapid phase of growth followed by a return to steady state, but the mechanisms that control growth are unknown. Quantification of coat protein complex (COP) II assembly revealed a dramatic up-regulation at exit sites driven by increased levels of Golgi proteins in t...
متن کاملSNARE Selectivity of the COPII Coat
The COPII coat buds transport vesicles from the endoplasmic reticulum that incorporate cargo and SNARE molecules. Here, we show that recognition of the ER-Golgi SNAREs Bet1, Sed5, and Sec22 occurs through three binding sites on the Sec23/24 subcomplex of yeast COPII. The A site binds to the YNNSNPF motif of Sed5. The B site binds to Lxx-L/M-E sequences present in both the Bet1 and Sed5 molecule...
متن کاملMolecular Recognition of Cargo by the COPII Complex A Most Accommodating Coat
The molecular mechanism by which diverse cargo proteins are recognized and exported from the ER has been unclear. Two papers in this issue of Cell add clarity by mapping multiple cargo recognition sites in the Sec24 subunit of the COPII coat complex and demonstrating roles for these sites in export of specific protein cargos from the ER.
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2012
ISSN: 0361-8609
DOI: 10.1002/ajh.23292